Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → HCID 67258000, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-(4-Fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 2760593 | — |
| 반응물 | HCID 67258967 | HCID 67258967 | — |
| 촉매 | Dichlorobis(tricyclohexylphosphine)pallium (II) | HCID 11050900 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 67258000 | HCID 67258000 | — |
반응 단계
Tert-butyl 4-{6-bromo-1-[(3-ethyl-1,2,4-oxadiazol-5-yl)methyl]-2,4-dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (500 mg, compound B99), 2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (246 mg), dichlorobis(tricyclohexylphosphine)palladium (68 mg) and aqueous cesium carbonate solution (0.694 ml, 2.0 M) in dioxane (18 ml) are reacted according to the procedure described in example B55 to afford the title compound after purification by flash column chromatography [silica gel, elution gradient: DCM/EtOH, 100/0 to 70/30 (v/v)] as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09018175B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-e4d8066f9ace4a9db4f523e27bbde9b4 |
| 출처 메모 | uspto-grants-2015_04 |