Potassium Carbonate → HCID 67258462, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate (1.16 g, compound B50) and 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride (500 mg, compound D31) in dry DMF (15 ml) is added potassium carbonate (753 mg). The mixture is stirred for 3 h at 50° C. and subsequently poured into ice-cold water. After stirring for 5 min the resulting precipitate is filtered off and dried in vacuo. The residue is taken up in EtOAc, filtered off and dried in vacuo to afford the title compound as a solid

Provenance & Evidence