Potassium Carbonate → HCID 67258349, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate (1.20 g, compound B50) and 2-(chloromethyl)-5-ethylthiophene (480 mg, compound D27) in dry DMF (15 ml) is added potassium carbonate (778 mg). The mixture is stirred for 1 h at 100° C. and subsequently poured into ice-cold water. After stirring for 5 min the resulting precipitate is filtered off and dried in vacuo. The residue is purified by flash column chromatography [silica gel, eluent: cyclohexane/EtOAc, 5/1 (v/v)] to afford the title compound as a solid.

Provenance & Evidence