Hydrochloric Acid → 1-{[3-(3-methoxypropyl)-1,2,4-oxadiazol-5-yl]methyl}-6-phenyl-3-(piperidin-4-yl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione hydrochloride

Participants

Reaction Steps

Tert-butyl 4-[1-{[3-(3-methoxypropyl)-1,2,4-oxadiazol-5-yl]methyl}-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl]piperidine-1-carboxylate (780 mg, compound B68) is dissolved in a solution of hydrogen chloride in 1,4-dioxane (20 ml, 6.8 M). The reaction mixture is stirred for 30 min at RT. Then diethyl ether is added and the resulting precipitate is filtered off, washed with diethyl ether and dried in vacuo to afford the title compound as a solid.

Provenance & Evidence