Hydrochloric Acid → 3-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoic acid

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Reaction Steps

To a solution of methyl 3-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate (0.5 g; compound C7) in 1,4-dioxane (8 ml) is added an 2 M aqueous solution of sodium hydroxide (1.3 ml) and the reaction mixture is stirred at RT for 12 h. An aqueous solution of hydrogen chloride (1.3 ml, 2.0 M) is added under stirring. The reaction mixture is evaporated to dryness in vacuo and the resulting residue is used for the next step without further purification.

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