Hydrochloric Acid → Sodium Chloride

Participants

Reaction Steps

To a solution of methyl 4-[(4aR,10bR)-9-ethoxy-8-methoxy-3,4,4a,10b-tetrahydro-1H-thiopyrano[4,3-c]isoquinolin-6-yl]benzoate (5.0 g; compound C9) in dioxane (40 ml) is added a 2.0 M aqueous sodium hydroxide solution (18.3 ml) and the reaction mixture is stirred for 1.5 h at RT. Afterwards a aqueous hydrogen chloride solution (1.83 ml, 2.0 M) is added and all volatiles are removed under vacuo to give the title compound with parts of sodium chloride.

Provenance & Evidence