Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate → HCID 89635743, compound

HRID 1476775Notes

Reaction equation

HRID 1476775 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[C@H:10]1[CH2:14][C@H:13]([F:15])[CH2:12][NH:11]1.Br[C:17]1[CH:22]=[CH:21][N:20]2[N:23]=[CH:24][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[C:19]2[CH:18]=1>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[C@H:10]1[CH2:14][C@H:13]([F:15])[CH2:12][N:11]1[C:17]1[CH:22]=[CH:21][N:20]2[N:23]=[CH:24][C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[C:19]2[CH:18]=1

Participants

3

Reactant 2

HCID 53249841Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylateHCID 117738211(2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidine hydrochloride

Product 1

HCID 89635743HCID 89635743, compound

Procedure

The title compound (Int-67) was prepared by the method similar to that for Int-84 using (2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidine hydrochloride (Int-47) and Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate to afford as yellow solid. LCMS (ESI): m/z 390.8 (M+H).

Workup

  1. customto afford as yellow solid

Sources & evidence

ORD record
ord-e16f05c112534780aad310b0466be754
Source dataset
uspto-grants-2016_08
Patent number
US09402833B2

Reaction notes

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