Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate → HCID 89635861, compound

HRID 1476776Notes

Reaction equation

HRID 1476776 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[C@H:10]1[CH2:14][C:13]([F:16])([F:15])[CH2:12][NH:11]1.Br[C:18]1[CH:23]=[CH:22][N:21]2[N:24]=[CH:25][C:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:20]2[CH:19]=1>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH:10]1[CH2:14][C:13]([F:15])([F:16])[CH2:12][N:11]1[C:18]1[CH:23]=[CH:22][N:21]2[N:24]=[CH:25][C:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[C:20]2[CH:19]=1

Participants

3

Reactant 2

HCID 53249841Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylateHCID 89618374HCID 89618374, compound

Product 1

HCID 89635861HCID 89635861, compound

Procedure

The title compound (Int-72) was prepared by the method similar to that for Int-84 using (R)-2-(2,5-difluorophenyl)-4,4-difluoropyrrolidine hydrochloride and Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate to afford as yellow solid. LCMS (ESI): m/z 408.1 (M+H).

Workup

  1. customto afford as yellow solid

Sources & evidence

ORD record
ord-f0087ca7544940939a7e73010b3825e8
Source dataset
uspto-grants-2016_08
Patent number
US09402833B2

Reaction notes

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