Hydrazinecarboxylic acid, ethyl ester → HCID 136597035, compound

Participants

Reaction Conditions

Reaction Steps

To crude (R)-tert-butyl 3-((3-cyanoisoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate was added ethyl hydrazinecarboxylate (1.104 g, 10.60 mmol). The reaction mixture was heated at 175° C. overnight and was subsequently cooled and diluted with EtOAc. The organic phase was washed with brine, dried over Na2SO4, and concentrated to give the title compound, which was used directly in the next step.

Provenance & Evidence