N-methyl-2-pyrrolidone → HCID 136597051, compound

Participants

Reaction Conditions

Reaction Steps

To a crude reaction mixture containing (S)-tert-butyl 3-((3-cyanoisoquinolin-1-yl)amino)pyrrolidine-1-carboxylate (717 mg) was added NMP (2 mL) and ethyl hydrazinecarboxylate (883 mg, 8.484 mmol). The reaction mixture was heated at 175° C. overnight and was subsequently cooled, diluted with EtOAc, and washed with aqueous NH4Cl. The organic layer was separated and concentrated to give the title compound, which was used directly in the next step.

Provenance & Evidence