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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1476857Generated: October 30, 2026

Hydrochloric Acid → HCID 136597043, compound

https://huagongshe.com/reaction/1476857

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 136597028HCID 136597028—
Solvent1,4-DioxaneHCID 31275—
ProductHydrochloric AcidHCID 313—
ProductHCID 136597043HCID 13659704388%

Reaction Steps

To (S)-tert-butyl 3-((6-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-1,7-naphthyridin-8-yl)oxy)pyrrolidine-1-carboxylate (100 mg, 0.251 mmol) suspended in dioxane (10 mL) was added 4M HCl in dioxane (0.251 mL, 1.004 mmol). The reaction mixture was stirred for 30 minutes and concentrated to give an HCl salt of the title compound (74 mg, 88%). This material was used directly in next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09402841B2
Source datasetuspto-grants-2016_08
ORD IDord-aa7b20f0130b40da82a980030b1467b8
Source noteuspto-grants-2016_08