HCID 136597024, compound → HCID 136596963, compound

HRID 1476866Notes

Reaction equation

HRID 1476866 reaction equation
[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:25]3[NH:29][C:28](=[O:30])[NH:27][N:26]=3)[N:8]=[C:9]2[O:12][C@H:13]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]2)=[CH:4][CH:3]=1>Cl.CCOC(C)=O>[F:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:25]3[NH:29][C:28](=[O:30])[NH:27][N:26]=3)[N:8]=[C:9]2[O:12][C@H:13]2[CH2:17][CH2:16][NH:15][CH2:14]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 136597024HCID 136597024, compound

Product 1

HCID 136596963HCID 136596963, compound

Reagents, catalysts & solvents 1

HCID 21866389Hydrogen chloride-ethyl acetateSolvent

Procedure

A solution of (S)-tert-butyl 3-((7-fluoro-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)isoquinolin-1-yl)oxy)pyrrolidine-1-carboxylate (70 mg, 0.15 mmol) in HCl/EtOAc (5 mL) was stirred at RT for 30 minutes. The mixture was subsequently concentrated in vacuo to give the title compound, which was used in the next step without further purification (60 mg, 100%). ESI-MS m/z [M+H]+ 316.

Workup

  1. concentrationThe mixture was subsequently concentrated in vacuo

Sources & evidence

ORD record
ord-2f34438538414e80ae319dc8fb09b5f4
Source dataset
uspto-grants-2016_08
Patent number
US09402841B2

Reaction notes

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