4-Fluoro-2-nitro-1-propoxybenzene → 5-Fluoro-2-propoxyaniline

HRID 1477123ノート

反応式

HRID 1477123 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH3:11])=[C:4]([N+:12]([O-])=O)[CH:3]=1>[C].[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH3:11])=[C:4]([CH:3]=1)[NH2:12]

参加物

4

反応物 1

HCID 669171744-Fluoro-2-nitro-1-propoxybenzene

生成物 1

HCID 261896335-Fluoro-2-propoxyaniline収率 86%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

4-Fluoro-2-nitro-1-propoxybenzene (2.0 g, 10.0 mmol) and 5% palladium carbon (750 mg) were added to ethanol (30 ml). Catalytic reduction was conducted at room temperature and atmospheric pressure (normal pressure). The catalyst was removed by celite filtration, and the filtrate was concentrated under reduced pressure. The residue was dissolved in dichloromethane, and dried over anhydrous magnesium sulfate. The resulting dry product was concentrated under reduced pressure to thereby obtain 1.45 g of oily red orange 5-fluoro-2-propoxyaniline (yield: 86%).

後処理

  1. customwas conducted at room temperature
  2. customThe catalyst was removed by celite filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. dissolutionThe residue was dissolved in dichloromethane
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationThe resulting dry product was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ef1cd020632c4d3a9900051e8e935898
出典データセット
uspto-grants-2016_08
特許番号
US09403773B2

反応ノート

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