反应详情

4-Fluoro-2-nitro-1-propoxybenzene (2.0 g, 10.0 mmol) and 5% palladium carbon (750 mg) were added to ethanol (30 ml). Catalytic reduction was conducted at room temperature and atmospheric pressure (normal pressure). The catalyst was removed by celite filtration, and the filtrate was concentrated under reduced pressure. The residue was dissolved in dichloromethane, and dried over anhydrous magnesium sulfate. The resulting dry product was concentrated under reduced pressure to thereby obtain 1.45 g of oily red orange 5-fluoro-2-propoxyaniline (yield: 86%).

1. customwas conducted at room temperature
2. customThe catalyst was removed by celite filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. dissolutionThe residue was dissolved in dichloromethane
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationThe resulting dry product was concentrated under reduced pressure