Boron tribromide → HCID 66917199, compound

HRID 1477145Notes

Reaction equation

HRID 1477145 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][C:9]([O:12]C)=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:14]1[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=1)=[CH:6][NH:7]2.B(Br)(Br)Br>ClCCl>[F:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[C:4](=[O:22])[C:5]([C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)=[CH:6][NH:7]2

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 66917251HCID 66917251, compound

Product 1

HCID 66917199HCID 66917199, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
-10 °C

Procedure

5-Fluoro-8-methoxy-3-(4-methoxyphenyl)-1H-quinolin-4-one (1.0 g, 3.34 mmol) was suspended in dichloromethane (40 ml), and the suspension was cooled to −10° C. in a methanol-ice bath. A 1N boron tribromide (17 ml) was added thereto, and the resulting mixture was stirred at room temperature for 15 hours. Ice water and dichloromethane were added to the reaction mixture, and the resultant insoluble matter was collected by filtration. The substance remaining on the filter was washed with water, dried and purified by silica gel column chromatography (dichloromethane:methanol=20:1→8:1→ethyl acetate:methanol=4:1). The purified product was concentrated under reduced pressure and ethyl acetate was then added to crystallize the residue. The crystals were collected by filtration, washed with ethyl acetate, and dried to thereby obtain 360 mg of powdery pale gray 5-fluoro-8-hydroxy-3-(4-hydroxyphenyl)-1H-quinolin-4-one (yield: 40%).

Workup

  1. filtrationthe resultant insoluble matter was collected by filtration
  2. washwas washed with water
  3. customdried
  4. custompurified by silica gel column chromatography (dichloromethane:methanol=20:1→8:1→ethyl acetate:methanol=4:1)
  5. concentrationThe purified product was concentrated under reduced pressure and ethyl acetate
  6. additionwas then added
  7. customto crystallize the residue
  8. filtrationThe crystals were collected by filtration
  9. washwashed with ethyl acetate
  10. customdried

Sources & evidence

ORD record
ord-a2ef9a57f11045f7bcf7ff3dfc7685e9
Source dataset
uspto-grants-2016_08
Patent number
US09403773B2

Reaction notes

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