Hydrochloric Acid → (S)-1-((S)-2-amino-2-phenyl-acetyl)-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester hydrochloride

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Reaction Steps

To (S)-1-((S)-2-tert-butoxycarbonylamino-2-phenyl-acetyl)-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester (2.78 g, 6.55 mmol, Eq: 1) was added 4 M HCl in dioxane (16.4 mL, 65.5 mmol, Eq: 10). The mixture was stirred at rt for 2 h. The solvent was removed in vacuo. After drying under vacuum, (S)-1-((S)-2-amino-2-phenyl-acetyl)-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester hydrochloride was obtained as an off-white solid which was used for next step without further purification.

Provenance & Evidence