Hydrochloric Acid → HCID 117871179, compound

Participants

Reaction Steps

((S)-1-{(S)-2-[(S)-2-(5-Fluoro-2-methyl-benzylcarbamoyl)-2,3-dihydro-indol-1-yl]-2-oxo-1-phenyl-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester (48 mg) was suspended in a 1:1 mixture of 4 M HCl in dioxane) and DCM and stirred at rt for 1 h. The solvent was removed in vacuo and the resulting solid was dissolved in CH3CN and water (3:1), and lyophilized to give (S)-1-[(S)-2-((S)-2-methylamino-propionylamino)-2-phenyl-acetyl]-2,3-dihydro-1H-indole-2-carboxylic acid 5-fluoro-2-methyl-benzylamide hydrochloride salt as a white powder (44 mg), m/z=503 (M+H).

Provenance & Evidence