Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Fluoropyridine | HCID 9746 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | HCID 70974730 | HCID 70974730 | — |
| Product | HCID 70974757 | HCID 70974757 | — |
Reaction Steps
A mixture of 2-(3-hydroxypropyl)-7-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one (25 mg, 0.069 mmol), Cs2CO3 (67 mg, 0.21 mmol) and 2-fluoropyridine (100 μL) was heated to 155° C. overnight. The reaction was concentrated and purified by reverse phase HPLC to afford 2-(3-(pyridin-2-yloxy)propyl)-7-(4-(trifluoromethoxy)phenyl)phthalazin-1(2H)-one as a white solid. C23H18F3N3O3. 441.9 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09403782B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-d9b139bdc55d42139c4e297a2ef01ddf |
|---|
| Source note | uspto-grants-2016_08 |
|---|
