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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 14773Generated: October 27, 2026

Methanesulfonyl chloride → N-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-N-(2-pyridin-4-yl-ethyl)-methanesulfonamide

https://huagongshe.com/reaction/14773

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
ReactantN-(3-(2-chloropyrimidin-4-yl)benzyl)-2-(pyridine-4-yl)ethanamineHCID 86603257—
ProductN-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-N-(2-pyridin-4-yl-ethyl)-methanesulfonamideHCID 86603258—

Reaction Steps

Intermediate 20 was coupled with methanesulfonyl chloride following procedure D. LC-MS showed the product had the expected M+H+ of 403.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07732444B2
Source datasetuspto-grants-2010_06
ORD IDord-41a4a1a85ecc4f3aa59fec68810e0abf
Source noteuspto-grants-2010_06