Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Sodium pentafluoropropionate | HCID 2733305 | — |
| Reactant | 2-Chloro-5-iodopyridine | HCID 4397176 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 122429679 | HCID 122429679 | — |
Reaction Steps
A mixture of 2-chloro-5-iodopyridine (20.0 g), sodium pentafluoropropionate (77.8 g), copper (I) iodide (31.8 g), xylene (84 ml) and N-methyl pyrrolidone (84 ml) was heated to 160° C., and stirred while heating under reflux 6 hours. The reaction mixture was cooled to room temperature, and water was poured thereto. Then, the mixture was extracted with methyl-tert-butyl ether. The organic layer was dried over sodium sulfate, and concentrated under reduced pressure to give 2-chloro-5-pentafluoroethyl pyridine 2-chloro-5-pentafluoroethyl pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09403771B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-fe7347f6edc54c8285f03ba1cc03464e |
|---|
| Source note | uspto-grants-2016_08 |
|---|
