Hydrochloric Acid → HCID 58487569, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 3-(3-amino-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate 26 (0.33 g, 0.00123 mol) was dissolved in 2 mL ethanol. Hydrochloric acid in ethanol (2.5 M) (2.00 mL, 0.00493 mol) was added and the mixture was heated to 40° C. for 1 hour. 12 mL of MTBE was added and the product precipitated from solution. The solids were filtered and washed with 2×5 mL MTBE, and recrystallized 3 times from methanol:isopropanol to give 127 mg white solid. MS (ESI) m/z 168 [M+1]+. 1H NMR (DMSO-d6) δ 1.67-1.82 (m, 3 H), 2.08-2.12 (d, 1 H), 2.86-2.90 (t, 1 H), 3.06-3.12 (t, 1 H), 3.21-3.24 (d, 1 H), 3.33 (s, 2H), 3.49-3.52 (d, 1 H), 6.32 (s, 2H).

Provenance & Evidence