HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → (2R,4S)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester | HCID 6951202 | — |
| Reactant | (2S,4S)-4-amino-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester | HCID 89776163 | — |
| Product | (2R,4S)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester | HCID 89776149 | — |
Reaction Steps
(2R,4S)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester was prepared from (2R,4R)-4-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester in a similar reaction sequence used in the preparation of (2S,4S)-4-amino-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid methyl ester. MS calcd. for C13H25N2O2 [(M+H)+] 241, obsd. 241.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403805B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-a2bb971f81994e0996d504203207cda7 |
| Source note | uspto-grants-2016_08 |