Azetidine → HCID 71715234, compound

HRID 1477551Notes

Reaction equation

[CH:1]1([CH2:7][N:8]2[CH2:12][C@@H:11]([NH:13][C:14]([C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]=3[OH:26])=[O:15])[CH2:10][C@H:9]2[C:27](O)=[O:28])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:30]1[CH2:33][CH2:32][CH2:31]1>>[N:30]1([C:27]([C@H:9]2[N:8]([CH2:7][CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH2:12][C@@H:11]([NH:13][C:14]([C:16]3[CH:25]=[CH:24][C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]=3[OH:26])=[O:15])[CH2:10]2)=[O:28])[CH2:33][CH2:32][CH2:31]1

Participants

Reactant 2

HCID 10422Azetidine

HCID 89768055HCID 89768055, compound

Product 1

HCID 71715234HCID 71715234, compound

Procedure

Hydroxy-naphthalene-2-carboxylic acid [(3S,5S)-5-(azetidine-1-carbonyl)-1-cyclohexylmethyl-pyrrolidin-3-yl]-amide was prepared from (2S,4S)-1-cyclohexylmethyl-4-[(1-hydroxy-naphthalene-2-carbonyl)-amino]-pyrrolidine-2-carboxylic acid and azetidine in an analogous manner to example 1. MS calcd for C26H34N3O3 [(M+H)+] 436.0, obsd. 436.0.

Sources & evidence

ORD record: ord-ba5a822d63664d5eaf13a83e277ac952
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09403805B2

Reaction notes

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