Hydrochloric Acid → 6-Chloro-4-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazin-2(1H)-one

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Reaction Steps

To a tetrahydrofuran solution (200 mL) of 2,4-dichloro-6-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazine (21.0 g, 63 mmol) synthesized in Reference Synthesis Example 1, 1 M sodium hydroxide aqueous solution (128 mL, 128 mmol) was added at room temperature and the resultant solution was stirred for 1 day. To the reaction solution, 1 M sodium hydroxide aqueous solution (32 mL, 32 mmol) was added and the resultant mixture was stirred for 6 hours. To the reaction solution, 1 M sodium hydroxide aqueous solution (19 mL, 19 mmol) was further added and the resultant solution was stirred for 2 hours. After completion of the reaction, pH of the reaction solution was adjusted to 4 by adding 1 M hydrochloric acid. After removing impurities, the resultant mixture was concentrated under reduced pressure to obtain a solid. The solid was collected by filtration, washed with water, and dried under reduced pressure to obtain the title compound (15.2 g, yield 79%).

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