Trifluoroacetic acid → HCID 117839396, compound

Participants

Reaction Steps

To a dichloromethane solution (92 mL) of tert-butyl 4-[5-(4-chlorobenzyl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl]piperazine-1-carboxylate (9.20 g, 22.7 mmol) synthesized in Reference Synthesis Example 8, trifluoroacetic acid (40 mL) was added and the resultant solution was stirred at room temperature for 4 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and pH was adjusted to 7 by adding water and saturated sodium bicarbonate aqueous solution. Extraction with ethyl acetate from the resultant liquid was performed three times, and the organic layer was washed with brine. A deposited solid was collected by filtration, washed with water and ethyl acetate, and dried under reduced pressure to obtain the title compound (3.18 g, yield 46%).

Provenance & Evidence