Sodium Hydroxide → 6-Chloro-4-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-1,3,5-triazin-2(1H)-one

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Reaction Steps

1-(4,6-Dichloro-1,3,5-triazin-2-yl)-4-(4-fluorophenyl)piperidin-4-ol (304 mg, 0.89 mmol) synthesized in Reference Synthesis Example 12 and 1 M sodium hydroxide aqueous solution (1.80 mL, 1.80 mmol) were used to obtain the title compound (169 mg, yield 59%) by synthesis in a similar manner to Reference Synthesis Example 2.

Provenance & Evidence