HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-4-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-1,3,5-triazin-2(1H)-one → HCID 178517890, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-4-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-1,3,5-triazin-2(1H)-one | HCID 136933051 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Product | HCID 178517890 | HCID 178517890 | 122.9% |
Reaction Steps
6-Chloro-4-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-1,3,5-triazin-2(1H)-one (239 mg, 0.74 mmol) synthesized in Reference Synthesis Example 13 and palladium hydroxide-activated carbon catalyst (24 mg) were used to obtain the title compound (264 mg, quantitative) by synthesis in a similar manner to Reference Synthesis Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403798B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-82ceee9d3fdb4d46965187001dd64c8a |
| Source note | uspto-grants-2016_08 |