反应详情

温度

80 °C

An acetic acid solution of 2,4-dichloro-6-[4-(4-fluorophenyl)piperazin-1-yl]-1,3,5-triazine (2.40 g, 7.31 mmol) synthesized in Reference Synthesis Example 1 and sodium acetate (1.80 g) was stirred at 80° C. for 8 hours. After completion of the reaction, the reaction solution was poured into water and the obtained solid was collected by filtration. Extraction with ethyl acetate was performed from the filtrate and the resultant ethyl acetate phase was concentrated under reduced pressure. The residue and the solid collected by filtration were combined and the combination was suspended into ethyl acetate, collected by filtration, washed with ethyl acetate, and dried under reduced pressure to obtain the title compound (1.82 g, yield 86%).

1. customAfter completion of the reaction
2. filtrationthe obtained solid was collected by filtration
3. extractionExtraction with ethyl acetate
4. concentrationthe resultant ethyl acetate phase was concentrated under reduced pressure
5. filtrationThe residue and the solid collected by filtration
6. filtrationcollected by filtration
7. washwashed with ethyl acetate
8. customdried under reduced pressure