Sodium Hydroxide → 6-Chloro-4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl]-1,3,5-triazin-2(1H)-one

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Reaction Steps

The crude product of 4-(4-chlorophenyl)-1-(4,6-dichloro-1,3,5-triazin-2-yl)piperidin-4-ol (10.0 mmol) synthesized in Reference Synthesis Example 20 and 1 M sodium hydroxide aqueous solution (120.0 mL, 120 mmol) were used to obtain the title compound (3.19 g, yield 93%) by synthesis in a similar manner to Reference Synthesis Example 2.

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