1-Bromo-4-fluorobenzene → HCID 117848941, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, a toluene solution (4 mL) of tert-butyl (R)-piperidin-3-yl-carbamate (500 mg, 2.50 mmol), 4-bromo-1-fluorobenzene (0.250 mL, 2.28 mmol), 2-(di-tert-butylphosphino)biphenyl (136 mg, 0.500 mmol), tris(dibenzylideneacetone)dipalladium (0) (104 mg, 0.130 mmol), and sodium tert-butoxide (307 mg, 3.50 mmol) was stirred at 100° C. for 4 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and purified by silica gel column chromatography (hexane/ethyl acetate=100/0→70/30 (v/v)) to obtain the title compound (550 mg, yield 82%).

Provenance & Evidence