1,4-Dioxane hydrochloride → HCID 117839781, compound

HRID 1477584Notes

Reaction equation

HRID 1477584 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([NH:14]C(=O)OC(C)(C)C)[CH2:9]2)=[CH:4][CH:3]=1.[ClH:22].O1CCOCC1>>[ClH:22].[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([NH2:14])[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 117848941HCID 117848941, compound

Product 1

HCID 117839781HCID 117839781, compound

Procedure

To tert-butyl (R)-[1-(4-fluorophenyl)piperidin-3-yl]carbamate (250 mg, 0.85 mmol) synthesized in Reference Synthesis Example 25, 4 M hydrogen chloride/1,4-dioxane solution (2.5 mL) was added and the resultant mixture was stirred at room temperature for 18 hours. After completion of the reaction, the resultant solid was collected by filtration to obtain the title compound (220 mg, quantitative).

Workup

  1. additionwas added
  2. customAfter completion of the reaction
  3. filtrationthe resultant solid was collected by filtration

Sources & evidence

ORD record
ord-b8868d941d334543895c47964168ba79
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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