Chloroform → HCID 10932702, compound

HRID 1477603Notes

Reaction equation

HRID 1477603 reaction equation
[CH:1]([Cl:4])(Cl)Cl.[C:5]([C:9]1[CH:13]=[C:12](CO)[NH:11][N:10]=1)([CH3:8])([CH3:7])[CH3:6].S(Cl)(Cl)=O>ClCCl>[C:5]([C:9]1[CH:13]=[C:12]([CH2:1][Cl:4])[NH:11][N:10]=1)([CH3:8])([CH3:7])[CH3:6]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 10943295HCID 10943295, compound

Product 1

HCID 10932702HCID 10932702, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a chloroform (20 mL)-dichloromethane (10 mL) mixed solution of [3-(tert-butyl)-1H-pyrazol-5-yl]methanol (617 mg, 4.00 mmol), thionyl chloride (577 μL, 8.01 mmol) was added at room temperature and the resultant solution was stirred at room temperature for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain a crude product (931 mg) of the title compound.

Workup

  1. additionwas added at room temperature
  2. customAfter completion of the reaction
  3. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6247235039294dd9ac522887883232fa
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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