1,4-Dioxane hydrochloride → HCID 72716407, compound

HRID 1477604Notes

Reaction equation

HRID 1477604 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH:9]2[CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[CH:4][CH:3]=1.[ClH:20].O1CCOCC1>>[ClH:20].[F:1][C:2]1[CH:3]=[CH:4][C:5]([S:8][CH:9]2[CH2:12][NH:11][CH2:10]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 117839681HCID 117839681, compound

Product 1

HCID 72716407HCID 72716407, compound

Procedure

To tert-butyl 3-[(4-fluorophenyl)thio]azetidine-1-carboxylate (139 mg, 0.49 mmol) synthesized in Reference Synthesis Example 64, 4 M hydrogen chloride/1,4-dioxane solution (1.0 mL) was added and the resultant solution was stirred at 0° C. for 30 minutes and at room temperature for 2 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain a crude product (119 mg) of the title compound.

Workup

  1. additionwas added
  2. customAfter completion of the reaction
  3. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3df950b8a901420e8b95f5d25d9b57f9
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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