Thionyl Chloride → 6-(Chloromethyl)-1,3-benzothiazole

HRID 1477605Notes

Reaction equation

HRID 1477605 reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([CH2:10]O)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:3]=[CH:2][S:1][C:5]=2[CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178603856-(Hydroxymethyl)benzothiazole

Product 1

HCID 229057716-(Chloromethyl)-1,3-benzothiazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a dichloromethane solution (1.2 mL) of benzo[d]thiazol-6-yl-methanol (60 mg, 0.36 mmol), thionyl chloride (53 μL) was added at room temperature and the resultant solution was stirred for 1 day. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain a crude product of the title compound.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-85233e78dff84b6e92a6f70fdca9bdc8
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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