HCID 117839630, compound → HCID 66961869, compound

Participants

Reaction Conditions

Reaction Steps

A methanol suspension (4.6 mL) of (3R,4R)-4-(dibenzylamino)-1-(4-fluorophenyl)pyrrolidin-3-ol (230 mg, 0.61 mmol) synthesized in Reference Synthesis Example 73 and palladium hydroxide-activated carbon catalyst (23 mg) was stirred under hydrogen atmosphere at 50° C. for 1 day. After completion of the reaction, the suspension was filtered with Celite and the filtrate was concentrated under reduced pressure to obtain a crude product (146 mg) of the title compound.

Provenance & Evidence