Formaldehyde → HCID 117839327, compound

HRID 1477626Notes

Reaction equation

HRID 1477626 reaction equation
[F:1][C:2]([C:5]1[CH:9]=[CH:8][NH:7][N:6]=1)([F:4])[CH3:3].[CH2:10]=[O:11]>C(O)C>[F:1][C:2]([C:5]1[CH:9]=[CH:8][N:7]([CH2:10][OH:11])[N:6]=1)([F:4])[CH3:3]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 178461131HCID 178461131, compound

Product 1

HCID 117839327HCID 117839327, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an ethanol solution (1.0 mL) of 3-(1,1-difluoroethyl)-1H-pyrazole (145 mg, 1.09 mmol) synthesized in Reference Synthesis Example 118, a formalin aqueous solution (1.0 mL) was added and the resultant mixture was stirred at 70° C. for 1 hour. After completion of the reaction, the reaction solution was concentrated under reduced pressure to obtain the title compound as a crude product.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8aa5bad172514d9889f1bf953cd56ddc
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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