Hydrazine hydrate (1:1) → HCID 117839662, compound

Participants

Reaction Steps

To an ethanol solution (5.0 mL) of tert-butyl 5-(1,3-dioxoisoindolin-2-yl)-4-(4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (500 mg, 2.36 mmol) synthesized in Reference Synthesis Example 201, hydrazine monohydrate (177 mg, 7.08 mmol) was added and the resultant mixture was stirred under reflux by heating for 5 hours. After completion of the reaction, the reaction solution was filtered and the filtrate was concentrated under reduced pressure. Chloroform was added to the obtained residue and the resultant mixture was filtered again, followed by concentrating the resultant filtrate under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain the title compound (150 mg, yield 22%).

Provenance & Evidence