Triethylamine → HCID 117933012, compound

Participants

Reaction Steps

To a tetrahydrofuran solution (2.0 mL) of tert-butyl 5-amino-4-(4-fluorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate (100 mg, 0.342 mmol) synthesized in Reference Synthesis Example 202, triethylamine (52.0 μL, 0.374 mmol), and N,N-dimethyl-4-aminopyridine (2.00 mg, 0.0170 mmol) were added, and then methanesulfonyl chloride (29.0 μL, 0.374 mmol) was added at 0° C. with stirring, followed by stirring the resultant reaction solution for 2 hours. After completion of the reaction, saturated ammonium chloride aqueous solution was added to the reaction solution and extraction from the resultant mixture with ethyl acetate was performed. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain a crude product of the title compound.

Provenance & Evidence