Sodium Hydroxide → HCID 117839410, compound

Participants

Reaction Steps

To a tetrahydrofuran solution (40 mL) of 3-benzyl-6-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-2-one (956 mg, 3.40 mmol) synthesized in Reference Synthesis Example 238, lithium aluminum hydride (258 mg, 6.80 mmol) was added at 0° C. and the resultant mixture was stirred under reflux by heating for 30 minutes. After completion of the reaction, 1 M sodium hydroxide aqueous solution was added to the reaction solution at 0° C. and extraction from the resultant mixture with dichloromethane was performed. The organic layer was purified by silica gel (amino-based) column chromatography (hexane/ethyl acetate=15/1→10/1) to obtain the title compound (593 mg, yield 66%).

Provenance & Evidence