4-Fluorophenylboronic acid → HCID 117839453, compound

HRID 1477656Notes

Reaction equation

HRID 1477656 reaction equation
Br[C:2]1[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[CH:6]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([C:2]2[NH:3][CH:4]=[C:5]([N+:7]([O-:9])=[O:8])[CH:6]=2)=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 117839844HCID 117839844, compound

Product 1

HCID 117839453HCID 117839453, compoundYield 40%

Procedure

2-Bromo-4-nitro-1H-pyrrole (886 mg, 4.64 mmol) synthesized in Reference Synthesis Example 244 and 4-fluorophenylboronic acid (779 mg, 5.57 mmol) were used to obtain the title compound (383 mg, yield 40%) by synthesis in a similar manner to Reference Synthesis Example 139.

Sources & evidence

ORD record
ord-531d596c0d384d679d56af60c8241ceb
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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