HCID 117839581, compound → HCID 83855568, compound

Participants

Reaction Steps

To 2-(4-fluorophenyl)-1-methyl-4-nitro-1H-pyrrole (200 mg, 1.03 mmol) synthesized in Reference Synthesis Example 246, acetic acid (2.0 mL) and platinum oxide (20.0 mg) were added and the resultant solution was stirred under hydrogen atmosphere at room temperature for 3 days. After completion of the reaction, the reaction solution was filtered with Celite and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel (amino-based) column chromatography (chloroform/methanol=1/0→1/1) to obtain the title compound (15.0 mg, yield 7%).

Provenance & Evidence