Phosphorus oxychloride → HCID 117839343, compound

Participants

Reaction Conditions

Reaction Steps

A phosphorus oxychloride solution (3.0 mL) of 2-({[3-(4-chlorobenzyl)ureido](methylthio)methylene}amino)-2-oxoethyl acetate (201 mg, 0.616 mmol) synthesized in Reference Synthesis Example 327 was stirred at 80° C. for 3 hours. After completion of the reaction, the reaction solution was added to chloroform-saturated sodium bicarbonate aqueous solution and extraction from the resultant mixture with chloroform was performed. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=2/1→0/1) to obtain the title compound (219 mg, quantitative).

Provenance & Evidence