反应详情

温度

0 °C

To an acetic acid (9.0 mL)-water (1.8 mL) solution of 2-chloro-4-[4-(4-fluorophenyl)-5,6-dihydropyridin-1(2H)-yl]-1,3,5-triazine (900 mg, 3.10 mmol) synthesized in Reference Synthesis Example 341, sodium acetate (900 mg, 11.0 mmol) was added and the resultant mixture was stirred at 90° C. for 1 hour. After completion of the reaction, the reaction solution was concentrated under reduced pressure and water was added to the obtained residue, followed by stirring the resultant mixture at 0° C. The precipitated solid was collected by filtration and the solid was dried under reduced pressure to obtain the title compound (750 mg, yield 89%).

1. additionwas added
2. customAfter completion of the reaction
3. concentrationthe reaction solution was concentrated under reduced pressure and water
4. additionwas added to the obtained residue
5. filtrationThe precipitated solid was collected by filtration
6. customthe solid was dried under reduced pressure