2-(Chloromethyl)-5-(trifluoromethyl)thiophene → 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2H)-yl]-1-{[5-(trifluoromethyl)thiophen-2-yl]methyl}-1,3,5-triazin-2(1H)-one

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Reaction Steps

4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-1(2H)-yl]-1,3,5-triazin-2-ol (3.32 g, 10.9 mmol) synthesized in Reference Synthesis Example 345 and 2-(chloromethyl)-5-(trifluoromethyl)thiophene were used to obtain the title compound (2.36 g, yield 46%) by synthesis in a similar manner to Reference Synthesis Example 16.

Provenance & Evidence