4-Methyloxybenzyl chloride → 4-[4-(4-Fluorophenyl)-5,6-dihydropyridin-1(2H)-yl]-1-(4-methoxybenzyl)-1,3,5-triazin-2(1H)-one

HRID 1477684Notes

Reaction equation

HRID 1477684 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11]([C:14]3[N:19]=[CH:18][NH:17][C:16](=[O:20])[N:15]=3)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[CH2:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11]([C:14]3[N:19]=[CH:18][N:17]([CH2:22][C:23]4[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=4)[C:16](=[O:20])[N:15]=3)[CH2:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 178517880HCID 178517880, compound

Product 1

HCID 1178396084-[4-(4-Fluorophenyl)-5,6-dihydropyridin-1(2H)-yl]-1-(4-methoxybenzyl)-1,3,5-triazin-2(1H)-oneYield 82%

Procedure

4-[4-(4-Fluorophenyl)-5,6-dihydropyridin-1(2H)-yl]-1,3,5-triazin-2(1H)-one (294 mg, 1.08 mmol) synthesized in Reference Synthesis Example 342 and 1-(chloromethyl)-4-methoxybenzene (162 μL, 1.19 mmol) were used to obtain the title compound (346 mg, yield 82%) by synthesis in a similar manner to Reference Synthesis Example 16.

Sources & evidence

ORD record
ord-6cbd7ea02b59425cb2490f274fe9d754
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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