Formaldehyde → HCID 117839856, compound

Participants

Reaction Conditions

Reaction Steps

To tert-butyl 4-oxopiperidine-1-carboxylate (1.00 g, 5.02 mmol), water (2.0 mL) and potassium carbonate (10.4 mg, 0.0750 mmol) were added at room temperature and thereafter the mixture was heated to 40° C., followed by adding formaldehyde (36% aqueous solution) (0.795 mg, 9.54 mmol) and stirring the resultant mixture for 2 hours. After completion of the reaction, the reaction solution was purified by silica gel column chromatography (hexane/ethyl acetate=1/2) to obtain the title compound (52.0 mg, yield 4%).

Provenance & Evidence