Trifluoroacetic acid → HCID 117840073, compound

Participants

Reaction Steps

To a dichloromethane solution (1.0 mL) of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-{[3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-1,3,5-triazin-2(1H)-one (14 mg, 0.03 mmol) synthesized in Reference Synthesis Example 91a, trifluoroacetic acid (0.5 mL) was added and the resultant mixture was stirred at room temperature for 3 hours. After the completion of the reaction, the reaction solution was concentrated under reduced pressure and to the resultant concentrate, water and saturated sodium hydrogen carbonate aqueous solution were added. A deposited solid was washed with water and was dried under reduced pressure to obtain the title compound (7.4 mg, yield: 55%).

Provenance & Evidence