Trifluoroacetic acid → HCID 117925755, compound

Participants

Reaction Steps

To 1-(4-chlorobenzyl)-4-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]-1,3,5-triazin-2(1H)-one (240 mg, 0.58 mmol) synthesized in Synthesis Example 111, trifluoroacetic acid (2.3 mL) was added and the resultant mixture was stirred at room temperature for 1 hour. After the completion of the reaction, the reaction solution was concentrated under reduced pressure and the resultant residue was purified by silica gel (amino-type) column chromatography (hexane/ethyl acetate=1/1) to obtain the title compound (44 mg, yield: 19%).

Provenance & Evidence