Cesium carbonate → HCID 117925825, compound

Participants

Reaction Steps

To an N,N-dimethylformamide solution of 4-[4-(4-fluorophenyl)-5,6-dihydropyridin-1(2H)-yl]-1-(4-hydroxybenzyl)-1,3,5-triazin-2(1H)-one (10.0 mg, 0.0260 mmol) synthesized in Synthesis Example 483a, cesium carbonate (10.3 mg, 0.0320 mmol) and 2,2,2-trifluoroethyl trifluoromethanesulfonate (4.57 μL, 0.0320 mmol) were added and the resultant mixture was stirred at 70° C. for 2 and a half hours. After the completion of the reaction, the reaction solution was concentrated under reduced pressure and the resultant residue was purified by silica gel column chromatography (chloroform/ethyl acetate=1/1) to obtain the title compound (2.43 mg, yield: 14%).

Provenance & Evidence