関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | 3-Chloropyridine-4-carbonitrile | HCID 10678306 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Ethoxyisonicotinonitrile | HCID 12866695 | — |
反応手順
Sodium ethoxide (53 mg, 0.74 mmol) was added to a 0° C. solution of 3-chloro-4-cyanopyridine (100 mg, 0.72 mmol) in DMF (1 mL). The mixture was stirred at 0° C. for 30 min and at rt for 2 h, then the mixture was concentrated in vacuo. To the residue Et2O was added, and the salts were filtered off. The filtrate was concentrated in vacuo to yield the title compound as a white solid. LC-MS A: tR=0.67 min; [M(35Cl)+H]+=149.06.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09403813B2 |
|---|
| 出典データセット | uspto-grants-2016_08 |
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| ORD ID | ord-7d5c05e1d6704c8ca673b97cdd0a36fe |
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| 出典メモ | uspto-grants-2016_08 |
|---|
