HCID 86688406, compound → HCID 86688405, compound

HRID 1477755Notes

Reaction equation

HRID 1477755 reaction equation
[CH3:1][N:2]1[C:10]([NH:11][C:12]([NH:14]C(=O)C2C=CC=CC=2)=[S:13])=[C:9]2[C:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)=[N:3]1>[OH-].[Na+]>[CH3:1][N:2]1[C:10]([NH:11][C:12]([NH2:14])=[S:13])=[C:9]2[C:4]([CH2:5][CH2:6][CH2:7][CH2:8]2)=[N:3]1

Participants

3

Reactant 1

HCID 86688406HCID 86688406, compound

Product 1

HCID 86688405HCID 86688405, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
90 °C

Procedure

A suspension of compound 18 (3 g, 9.5 mmol) in 30 mL of 5% NaOH aqueous solution was stirred in an oil bath of 90° C. for 8 hrs and cooled down to room temperature. Ice was added while stirring to the reaction mixture. The resulting suspension was filtered, and the cake was washed with cold water (10 mL×3) and further dried in vacuo to afford the desired product 5 as an off-white powder.

Workup

  1. temperaturecooled down to room temperature
  2. additionIce was added
  3. stirringwhile stirring to the reaction mixture
  4. filtrationThe resulting suspension was filtered
  5. washthe cake was washed with cold water (10 mL×3)
  6. customfurther dried in vacuo

Sources & evidence

ORD record
ord-642c34ab3f6943c09546266657bd2350
Source dataset
uspto-grants-2016_08
Patent number
US09403815B2

Reaction notes

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